环境污染物对睾丸功能的影响。
The effect of environmental contaminants on testicular function.
机构信息
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Pondicherry 605 014, India.
出版信息
Asian J Androl. 2011 Jul;13(4):585-91. doi: 10.1038/aja.2011.40. Epub 2011 Jun 27.
Abstract
Male reproductive health has deteriorated considerably in the last few decades. Nutritional, socioeconomic, lifestyle and environmental factors (among others) have been attributed to compromising male reproductive health. In recent years, a large volume of evidence has accumulated that suggests that the trend of decreasing male fertility (in terms of sperm count, quality and other changes in male reproductive health) might be due to exposure to environmental toxicants. These environmental contaminants can mimic natural oestrogens and target testicular spermatogenesis, steroidogenesis, and the function of both Sertoli and Leydig cells. Most environmental toxicants have been shown to induce reactive oxygen species, thereby causing a state of oxidative stress in various compartments of the testes. However, the molecular mechanism(s) of action of the environmental toxicants on the testis have yet to be elucidated. This review discusses the effects of some of the more commonly used environmental contaminants on testicular function through the induction of oxidative stress and apoptosis.
摘要
在过去几十年中，男性生殖健康状况显著恶化。营养、社会经济、生活方式和环境因素（等等）被认为会损害男性生殖健康。近年来，大量证据表明，男性生育力下降的趋势（就精子数量、质量和男性生殖健康的其他变化而言）可能是由于暴露于环境毒物。这些环境污染物可以模拟天然雌激素，并针对睾丸精子发生、类固醇生成以及支持细胞和间质细胞的功能。大多数环境毒物已被证明会诱导活性氧，从而导致睾丸各个部位的氧化应激状态。然而，环境毒物对睾丸的作用的分子机制尚未阐明。这篇综述讨论了一些更常用的环境污染物通过诱导氧化应激和细胞凋亡对睾丸功能的影响。
相似文献
1
The effect of environmental contaminants on testicular function.环境污染物对睾丸功能的影响。
Asian J Androl. 2011 Jul;13(4):585-91. doi: 10.1038/aja.2011.40. Epub 2011 Jun 27.
2
Role of Oxidative Stress in Male Reproductive Dysfunctions with Reference to Phthalate Compounds.氧化应激在邻苯二甲酸酯类化合物所致男性生殖功能障碍中的作用
Urol J. 2015 Nov 14;12(5):2304-16.
3
Effect of environmental contaminants on mammalian testis.环境污染物对哺乳动物睾丸的影响。
Curr Mol Pharmacol. 2014;7(2):119-35. doi: 10.2174/1874467208666150126155420.
4
Environmental and occupational pesticide exposure and human sperm parameters: A Navigation Guide review.环境和职业性农药暴露与人类精子参数：一项循证综述。
Toxicology. 2022 Jan 15;465:153017. doi: 10.1016/j.tox.2021.153017. Epub 2021 Oct 29.
5
Environmental contaminants and male infertility: Effects and mechanisms.环境污染物与男性不育：影响及机制
Andrologia. 2021 Feb;53(1):e13646. doi: 10.1111/and.13646. Epub 2020 May 24.
6
Bisphenols Threaten Male Reproductive Health via Testicular Cells.双酚类物质通过睾丸细胞威胁男性生殖健康。
Front Endocrinol (Lausanne). 2020 Sep 11;11:624. doi: 10.3389/fendo.2020.00624. eCollection 2020.
7
Testicular Stem Cell Dysfunction Due to Environmental Insults Could Be Responsible for Deteriorating Reproductive Health of Men.环境因素对睾丸干细胞功能的损害可能是导致男性生殖健康恶化的原因。
Reprod Sci. 2021 Mar;28(3):649-658. doi: 10.1007/s43032-020-00411-3. Epub 2021 Jan 6.
8
The role of the Fas/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis: An update.Fas/FasL信号通路在环境毒物诱导的睾丸细胞凋亡中的作用：最新进展
Syst Biol Reprod Med. 2018 Apr;64(2):93-102. doi: 10.1080/19396368.2017.1422046. Epub 2018 Jan 4.
9
Induction of CYP2E1 in testes of isoniazid-treated rats as possible cause of testicular disorders.异烟肼治疗的大鼠睾丸中CYP2E1的诱导可能是睾丸疾病的原因。
Toxicol Lett. 2015 Apr 16;234(2):59-66. doi: 10.1016/j.toxlet.2015.02.008. Epub 2015 Feb 13.
10
Climate change, microplastics, and male infertility.气候变化、微塑料与男性不育。
Curr Opin Urol. 2024 Sep 1;34(5):366-370. doi: 10.1097/MOU.0000000000001201. Epub 2024 Jun 26.
引用本文的文献
1
Cell protective effects of vitamin C against oxidative stress induced by ciprofloxacin on spermatogenesis: involvement of cellular apoptosis.维生素C对环丙沙星诱导的精子发生氧化应激的细胞保护作用：细胞凋亡的参与
Front Cell Dev Biol. 2025 Mar 20;13:1489959. doi: 10.3389/fcell.2025.1489959. eCollection 2025.
2
Insecticides and testicular health: mechanisms of injury and protective natural products.杀虫剂与睾丸健康：损伤机制及天然保护产物
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 26. doi: 10.1007/s00210-025-04016-y.
3
The Various Mechanisms by Which Exercise-Induced Fatigue (EIF) Affects Spermatogenesis Through Testosterone.运动性疲劳（EIF）通过睾酮影响精子发生的各种机制。
Reprod Sci. 2025 Apr;32(4):965-976. doi: 10.1007/s43032-025-01804-y. Epub 2025 Feb 11.
4
Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2/SLC7A11/GPX-4 trajectory.通过激活NRF-2/SLC7A11/GPX-4信号通路，萝卜硫素可显著抑制成年大鼠因暴露于邻苯二甲酸二（2-乙基己基）酯而导致的睾丸铁死亡。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar;398(3):3163-3175. doi: 10.1007/s00210-024-03440-w. Epub 2024 Oct 1.
5
The interplay of transition metals in ferroptosis and pyroptosis.过渡金属在铁死亡和细胞焦亡中的相互作用。
Cell Div. 2024 Aug 3;19(1):24. doi: 10.1186/s13008-024-00127-9.
6
Influence of dietary supplementation with (Maca) on sperm quality in dogs.用玛咖进行膳食补充对犬类精子质量的影响。
Front Vet Sci. 2024 Feb 29;11:1375146. doi: 10.3389/fvets.2024.1375146. eCollection 2024.
7
Bisphenol-A disturbs hormonal levels and testis mitochondrial activity, reducing male fertility.双酚A会扰乱激素水平和睾丸线粒体活性，降低男性生育能力。
Hum Reprod Open. 2023 Nov 15;2023(4):hoad044. doi: 10.1093/hropen/hoad044. eCollection 2023.
8
A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells.氧化应激与药用植物对睾丸间质细胞影响的综述
Antioxidants (Basel). 2023 Aug 4;12(8):1559. doi: 10.3390/antiox12081559.
9
(Pomegranate) Peel Extract Pre-Treatment Alleviates Fenpropathrin-Induced Testicular Injury via Suppression of Oxidative Stress and Inflammation in Adult Male Rats.石榴皮提取物预处理通过抑制成年雄性大鼠的氧化应激和炎症来减轻甲氰菊酯诱导的睾丸损伤。
Toxics. 2023 Jun 3;11(6):504. doi: 10.3390/toxics11060504.
10
Adaptive responses of cardiorespiratory system and hormonal parameters to individualized high-intensity interval training using anaerobic power reserve in well-trained rowers.训练有素的赛艇运动员心肺系统和激素参数对基于无氧功率储备的个体化高强度间歇训练的适应性反应。
Front Physiol. 2023 Apr 24;14:1177108. doi: 10.3389/fphys.2023.1177108. eCollection 2023.
本文引用的文献
1
Environmental toxicants and male reproductive function.环境毒物与男性生殖功能
Spermatogenesis. 2011 Jan;1(1):2-13. doi: 10.4161/spmg.1.1.13971.
2
Effect of environmental contaminants on male reproduction.环境污染物对男性生殖的影响。
Environ Toxicol Pharmacol. 2006 Jan;21(1):34-41. doi: 10.1016/j.etap.2005.06.004. Epub 2005 Jul 26.
3
Fenvalerate induces germ cell apoptosis in mouse testes through the Fas/FasL signaling pathway.氰戊菊酯通过 Fas/FasL 信号通路诱导小鼠睾丸生殖细胞凋亡。
Arch Toxicol. 2011 Sep;85(9):1101-8. doi: 10.1007/s00204-011-0654-9. Epub 2011 Jan 30.
4
Mitochondrial signaling pathway is also involved in bisphenol A induced germ cell apoptosis in testes.线粒体信号通路也参与了双酚 A 诱导睾丸生殖细胞凋亡。
Toxicol Lett. 2010 Nov 30;199(2):129-35. doi: 10.1016/j.toxlet.2010.08.014. Epub 2010 Sep 8.
5
Effects of methoxychlor and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase-3 activities in human and rat testes.甲氧滴滴涕和2,2-双（对羟基苯基）-1,1,1-三氯乙烷对人和大鼠睾丸中3β-羟基类固醇脱氢酶及17β-羟基类固醇脱氢酶-3活性的影响。
Int J Androl. 2011 Apr;34(2):138-44. doi: 10.1111/j.1365-2605.2010.01065.x.
6
Tight junctions in the testis: new perspectives.睾丸中的紧密连接：新视角。
Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1621-35. doi: 10.1098/rstb.2010.0010.
7
Sertoli-germ cell junctions in the testis: a review of recent data.睾丸中支持细胞-生殖细胞连接：近期数据综述。
Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1593-605. doi: 10.1098/rstb.2009.0251.
8
Methoxychlor induces apoptosis via mitochondria- and FasL-mediated pathways in adult rat testis.甲氧滴滴涕通过线粒体和 FasL 介导的途径诱导成年大鼠睾丸细胞凋亡。
Chem Biol Interact. 2010 Apr 29;185(2):110-8. doi: 10.1016/j.cbi.2010.03.014. Epub 2010 Mar 12.
9
Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol.双酚 A 可能会像雌二醇一样，通过对睾丸和脑垂体系统产生不良影响而导致睾酮减少。
Toxicol Lett. 2010 Apr 15;194(1-2):16-25. doi: 10.1016/j.toxlet.2010.02.002. Epub 2010 Feb 6.
10
Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood.青春期和成年早期接触氰戊菊酯会破坏成年小鼠的类固醇生成和精子发生。
J Appl Toxicol. 2010 May;30(4):369-77. doi: 10.1002/jat.1507.
Zotero 插件