Departments of Neurology and Physical Medicine & Rehabilitation, University of Texas Medical School at Houston, Houston, TX 77030, USA.
Neurotherapeutics. 2011 Jul;8(3):452-62. doi: 10.1007/s13311-011-0057-x.
Stroke is the leading cause of long-term disability. The goal of stroke rehabilitation is to improve recovery in the years after a stroke and to decrease long-term disability. This article, titled "Rehabilitation--Emerging Technologies, Innovative Therapies, and Future Objectives" gives evidence-based information on the type of rehabilitation approaches that are effective to improve functional mobility and to address cognitive impairments. We review the importance of taking a translational approach to neurorehabilitation, considering the interaction of motor and cognitive systems, skilled learned purposeful limb movement, and spatial navigation ability. Known biologic mechanisms of neurorecovery are targeted in relation to technology implemented by members of the multidisciplinary team. Results from proof-of-concept, within subjects, and randomized controlled trials are presented, and the implications for optimal stroke rehabilitation strategies are discussed. Developing clinical practices are highlighted and future research directions are proposed with goals to provide insight on what the next steps are for this burgeoning discipline.
中风是长期残疾的主要原因。中风康复的目标是改善中风后数年的恢复情况，并降低长期残疾的程度。这篇题为“康复——新兴技术、创新疗法和未来目标”的文章提供了基于证据的信息，介绍了有助于改善功能移动性和解决认知障碍的康复方法类型。我们回顾了采取神经康复转化方法的重要性，考虑到运动和认知系统的相互作用、熟练的有目的的肢体运动以及空间导航能力。针对多学科团队成员实施的技术，研究了神经恢复的已知生物学机制。介绍了概念验证、个体内和随机对照试验的结果，并讨论了对最佳中风康复策略的影响。强调了正在发展的临床实践，并提出了未来的研究方向，目的是深入了解这一新兴学科的下一步发展方向。
