Yodmalai Songadul, Chiewchanvit Siri, Mahanupab Pongsak
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Southeast Asian J Trop Med Public Health. 2011 May;42(3):674-8.
The incidence of tuberculosis in renal transplant recipients is higher than in the general population. However, the incidence of cutaneous miliary tuberculosis in these patients is very rare. We report a 56-year-old renal transplant Thai man admitted to the hospital with prolong fever, dry cough and multiple small erythematous papules on his extremities. A chest X-ray revealed diffuse miliary infiltration. Mycobacterium tuberculosis DNA was demonstrated in bronchoalveolar lavage fluid by polymerase chain reaction. Histopathology of a skin biopsy showed poorly formed noncaseating granulomatous inflammation in the lower dermis and was positive for many acid-fast bacilli. Miliary tuberculosis of the lung and skin were diagnosed. The respiratory symptom and the skin lesions improved after treatment with anti-tuberculous drugs.
肾移植受者中结核病的发病率高于普通人群。然而,这些患者中皮肤粟粒性结核病的发病率非常罕见。我们报告一例56岁的泰国男性肾移植患者,因持续发热、干咳以及四肢出现多个小的红斑丘疹入院。胸部X线显示弥漫性粟粒状浸润。通过聚合酶链反应在支气管肺泡灌洗液中检测到结核分枝杆菌DNA。皮肤活检的组织病理学显示真皮下部有形成不良的非干酪样肉芽肿性炎症,且许多抗酸杆菌呈阳性。诊断为肺和皮肤粟粒性结核病。抗结核药物治疗后,呼吸道症状和皮肤病变有所改善。