Itaya T, Hashimoto H, Satoh R, Uematsu T, Nakashima M
Department of Pharmacology, Hamamatsu University School of Medicine, Japan.
Jpn J Pharmacol. 1990 Aug;53(4):513-8.
The alteration in adrenoceptors in the hypertrophied right ventricle of the rats with myocardial infarction (Ml) was examined. The density of alpha-1-adrenoceptors increased in four and twelve week old Ml rats but not in one week old Ml rats. The beta-adrenoceptors did not significantly change. It is probable that the increased density of alpha-adrenoceptors may be one of the causes for the increased responsiveness to the alpha-adrenergic agonist in the hypertrophied cardiac muscles of Ml rats.
研究了心肌梗死（MI）大鼠肥厚右心室中肾上腺素能受体的变化。在4周龄和12周龄的MI大鼠中，α-1-肾上腺素能受体密度增加，但1周龄的MI大鼠中未增加。β-肾上腺素能受体无明显变化。α-肾上腺素能受体密度增加可能是MI大鼠肥厚心肌对α-肾上腺素能激动剂反应性增加的原因之一。
