Naresh Kikkeri N, Raphael Martine, Ayers Leona, Hurwitz Nina, Calbi Valeria, Rogena Emily, Sayed Shahin, Sherman Omar, Ibrahim Hazem A H, Lazzi Stefano, Mourmouras Vasileios, Rince Patricia, Githanga Jessie, Byakika Bessie, Moshi Emma, Durosinmi Muheez, Olasode Babatunde J, Oluwasola Olayiwola A, Akang Effiong E, Akenòva Yetunde, Adde Melissa, Magrath Ian, Leoncini Lorenzo
Hammersmith Hospital & Imperial College, London, UKUniv Paris-Sud, Paris, FranceThe Ohio State University, Columbus, Ohio, USAUniversity of Basel, Basel, SwitzerlandSaint Mary Hospital, Lacor, Gulu, UgandaUniversity of NairobiAga Khan University Hospital, Nairobi, KenyaMansoura University, Mansoura, EgyptUniversity of Siena, Siena, ItalyNairobi Hospital, Nairobi, Kenya; Nairobi, KenyaMuhimbili National Hospital, Dares salaam, TanzaniaObafemi Awolowo University, Ile Ife, NigeriaU.C.H, Ibadan, NigeriaINCTR, Brussels, Belgium.
Br J Haematol. 2011 Sep;154(6):696-703. doi: 10.1111/j.1365-2141.2011.08772.x. Epub 2011 Jun 28.
Approximately 30 000 cases of non-Hodgkin lymphoma (NHL) occur in the equatorial belt of Africa each year. Apart from the fact that Burkitt lymphoma (BL) is very common among children and adolescents in Africa and that an epidemic of human immunodeficiency virus (HIV) infection is currently ongoing in this part of the world, very little is known about lymphomas in Africa. This review provides information regarding the current infrastructure for diagnostics in sub-Saharan Africa. The results on the diagnostic accuracy and on the distribution of different lymphoma subsets in sub-Saharan Africa were based on a review undertaken by a team of lymphoma experts on 159 fine needle aspirate samples and 467 histological samples during their visit to selected sub-Saharan African centres is presented. Among children (<18 years of age), BL accounted for 82% of all NHL, and among adults, diffuse large B-cell lymphoma accounted for 55% of all NHLs. Among adults, various lymphomas other than BL, including T-cell lymphomas, were encountered. The review also discusses the current strategies of the International Network of Cancer Treatment and Research on improving the diagnostic standards and management of lymphoma patients and in acquiring reliable clinical and pathology data in sub-Saharan Africa for fostering high-quality translational research.
非洲赤道地区每年约有3万例非霍奇金淋巴瘤（NHL）病例发生。除了伯基特淋巴瘤（BL）在非洲儿童和青少年中非常常见，以及该地区目前正在流行人类免疫缺陷病毒（HIV）感染外，人们对非洲淋巴瘤的了解非常少。本综述提供了有关撒哈拉以南非洲目前诊断基础设施的信息。关于撒哈拉以南非洲诊断准确性和不同淋巴瘤亚型分布的结果，是基于一组淋巴瘤专家在访问撒哈拉以南非洲选定中心期间，对159份细针穿刺抽吸样本和467份组织学样本进行审查后得出的。在儿童（<18岁）中，BL占所有NHL的82%，在成人中，弥漫性大B细胞淋巴瘤占所有NHL的55%。在成人中，还发现了除BL之外的各种淋巴瘤，包括T细胞淋巴瘤。本综述还讨论了国际癌症治疗和研究网络目前在提高撒哈拉以南非洲淋巴瘤患者诊断标准和管理水平，以及获取可靠临床和病理数据以促进高质量转化研究方面的策略。
