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推进白血病诊断与治疗:世界卫生组织支持的非洲实验室创新——一篇叙述性综述

Advancing Leukemia Diagnosis and Treatment: WHO-Supported Laboratory Innovations in Africa- A Narrative Review.

作者信息

Obeagu Emmanuel Ifeanyi

机构信息

Department of Biomedical and Laboratory Science, Africa University, Mutare, Zimababwe.

Department of Medical Laboratory Science, Kampala International University, Ishaka, Uganda.

出版信息

Blood Lymphat Cancer. 2025 Jun 24;15:47-67. doi: 10.2147/BLCTT.S518005. eCollection 2025.

Abstract

Leukemia remains a major health challenge in Africa, where limited access to advanced diagnostic technologies often leads to delayed diagnosis and suboptimal treatment outcomes. This review explores the role of WHO-supported laboratory innovations in advancing leukemia diagnosis across the continent. It examines key technologies such as molecular diagnostics, flow cytometry, and cytogenetics, highlighting how these innovations have enhanced the accuracy and speed of leukemia detection in resource-limited settings. By facilitating early and precise diagnoses, these technologies are improving patient management and treatment outcomes. Despite the promising advancements, significant barriers to widespread implementation persist, including high costs, inadequate infrastructure, and a shortage of trained personnel. WHO's efforts to address these challenges through regional collaborations, technical assistance, and capacity-building initiatives are pivotal in overcoming these obstacles. The establishment of specialized diagnostic centers and the integration of advanced technologies into national healthcare systems are key strategies to expand access and improve leukemia care in Africa.

摘要

白血病仍然是非洲面临的一项重大健康挑战,在非洲,先进诊断技术的获取有限常常导致诊断延误和治疗效果欠佳。本综述探讨了世界卫生组织支持的实验室创新在推动非洲大陆白血病诊断方面所发挥的作用。它审视了诸如分子诊断、流式细胞术和细胞遗传学等关键技术,突出了这些创新如何在资源有限的环境中提高了白血病检测的准确性和速度。通过促进早期和精确诊断,这些技术正在改善患者管理和治疗效果。尽管取得了令人鼓舞的进展,但广泛实施仍存在重大障碍,包括成本高昂、基础设施不足以及训练有素的人员短缺。世界卫生组织通过区域合作、技术援助和能力建设举措应对这些挑战的努力对于克服这些障碍至关重要。建立专门的诊断中心以及将先进技术整合到国家医疗系统中是扩大非洲白血病护理可及性并改善护理水平的关键战略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb5/12205951/08b166a9abb1/BLCTT-15-47-g0001.jpg

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