Department of Histopathology, Charing Cross Hospital, Imperial College Healthcare NHS Trust and Imperial College, London, UK.
Histopathology. 2011 Jun;58(7):1081-5. doi: 10.1111/j.1365-2559.2011.03838.x.
To present four new cases of in situ lobular neoplasia associated with marked proliferation of myoepithelial cells.
Four recently seen cases showing extensive foci of in situ lobular neoplasia, as confirmed by negative E-cadherin staining, were stained for myoepithelial cells using CD10, smooth muscle actin and cytokeratin 5/6. Invasive lobular carcinoma was also present in two cases; one case was associated with multiple foci of collagenous spherulosis, and one was associated with a radial scar. Marked myoepithelial proliferation was seen around most of the in situ lobular foci or mingled with lobular cells.
Marked proliferation of myoepithelial cells is sometimes encountered in association with extensive in situ lobular neoplasia. It is suggested that this proliferation might have a role in maintaining the in situ status of these lesions or, alternatively, that there is a shared factor responsible for the simultaneous proliferation of certain 'lobular' cell types and myoepithelial cells.
介绍 4 例伴有明显肌上皮细胞增殖的原位小叶肿瘤。
最近观察到 4 例广泛原位小叶肿瘤病例，通过 E-钙黏蛋白染色阴性证实，使用 CD10、平滑肌肌动蛋白和细胞角蛋白 5/6 对肌上皮细胞进行染色。其中 2 例还存在浸润性小叶癌；1 例与多个胶原球形成有关，1 例与放射状瘢痕有关。原位小叶肿瘤的大部分病灶周围或与小叶细胞混合存在明显的肌上皮细胞增殖。
在广泛的原位小叶肿瘤中有时会遇到明显的肌上皮细胞增殖。这提示这种增殖可能在维持这些病变的原位状态方面具有作用，或者存在共同的因素导致某些“小叶”细胞类型和肌上皮细胞的同时增殖。
