Ghorashi Ziaaedin, Nezami Nariman, Hoseinpour-Feizi Hamideh, Ghorashi Sona, Tabrizi Jafar Sadegh
Drug Applied Research Center, Tabriz University (Medical Sciences), Tabriz, Iran.
J Med Case Rep. 2011 Jun 27;5:241. doi: 10.1186/1752-1947-5-241.
Klebsiella pneumoniae is in most cases a hospital-acquired infection and presents as pneumonia, septicemia and meningitis in patients with some predisposing factors, including prematurity, intravenous catheter, history of antibiotic therapy and intravenous nutrients.
A low-birth-weight, 33-day-old Caucasian girl with respiratory distress syndrome was admitted to our hospital. She developed septicemia, meningitis, polyarticular arthritis and osteomyelitis by nosocomial K. pneumoniae which was resistant to most antibiotics except ciprofloxacin. She was therefore treated with ciprofloxacin and co-trimoxazole for eight weeks. After completion of the treatment course, she completely improved with excellent weight gain and without any adverse effects during three years of follow-up.
In the resistant strain of K. pneumoniae, ciprofloxacin could be considered as a therapeutic option with the prospect of a good outcome, even in neonates and infants.
肺炎克雷伯菌在大多数情况下是医院获得性感染,在有一些易感因素的患者中表现为肺炎、败血症和脑膜炎,这些因素包括早产、静脉导管、抗生素治疗史和静脉营养。
一名患有呼吸窘迫综合征的33天龄低体重白种女孩入住我院。她因医院内感染的肺炎克雷伯菌而患上败血症、脑膜炎、多关节关节炎和骨髓炎,该菌对除环丙沙星外的大多数抗生素耐药。因此,她接受了环丙沙星和复方新诺明治疗八周。治疗疗程结束后,她完全康复,体重增加良好,在三年的随访期间没有任何不良反应。
对于肺炎克雷伯菌耐药菌株,即使在新生儿和婴儿中,环丙沙星也可被视为一种有望取得良好疗效的治疗选择。