Department of General Surgery, First Clinic Medical School of Yangzhou University, Yangzhou, China.
BMC Cancer. 2011 Jun 27;11:277. doi: 10.1186/1471-2407-11-277.
HER-2/neu and VEGF expression is correlated with disease behaviors in various cancers. However, evidence for their expression in colon cancer is rather contradictory both for the protein expression status and prognostic value. HER-2/neu is found to participate in VEGF regulation, and has known correlation with VEGF expression in some tumors. In this study, we investigated HER-2/neu and VEGF expression in Chinese colon patients and explored whether there was any correlation between their expression patterns.
HER-2/neu and VEGF were investigated immunohistochemically using tumor samples obtained from 317 colon cancer patients with all tumor stages. Correlation of the degree of staining with clinicopathological parameters and survival was investigated.
Positive expression rates of HER-2/neu and VEGF in colon cancer were 15.5% and 55.5% respectively. HER-2/neu expression was significantly correlated with tumor size and distant metastases (P < 0.05), but was not an independent prognostic marker of survival (P > 0.05). Expression of VEGF was significantly correlated with tumor size, tumor stage, lymph node metastases, and distant metastases (P < 0.05). The 5-year survival rate in patients with negative and positive VEGF expression was 70.2% and 61.9% respectively; the difference was not statistically significant (P = 0.146). No correlation between HER-2/neu and VEGF expression was detected (P = 0.151).
HER-2/neu and VEGF are not important prognostic markers of colon cancer. The present results do not support any association between HER2/neu and VEGF expression in this setting.
HER-2/neu 和 VEGF 的表达与多种癌症的疾病行为相关。然而，其在结肠癌中的蛋白表达状态和预后价值的证据存在较大争议。HER-2/neu 被发现参与 VEGF 的调节，并且在一些肿瘤中与 VEGF 表达存在已知的相关性。在本研究中，我们调查了中国结肠癌患者中 HER-2/neu 和 VEGF 的表达情况，并探讨了它们的表达模式之间是否存在任何相关性。
使用来自 317 例各期结肠癌患者的肿瘤样本，通过免疫组织化学方法检测 HER-2/neu 和 VEGF 的表达。分析染色程度与临床病理参数和生存的相关性。
结肠癌中 HER-2/neu 和 VEGF 的阳性表达率分别为 15.5%和 55.5%。HER-2/neu 的表达与肿瘤大小和远处转移显著相关（P<0.05），但不是生存的独立预后标志物（P>0.05）。VEGF 的表达与肿瘤大小、肿瘤分期、淋巴结转移和远处转移显著相关（P<0.05）。VEGF 阴性和阳性表达患者的 5 年生存率分别为 70.2%和 61.9%；差异无统计学意义（P=0.146）。未检测到 HER-2/neu 和 VEGF 表达之间的相关性（P=0.151）。
HER-2/neu 和 VEGF 不是结肠癌的重要预后标志物。本研究结果不支持在此背景下 HER2/neu 和 VEGF 表达之间存在任何关联。
