Division of Allergy-Immunology and Rheumatology, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912-3790, USA.
Allergy Asthma Proc. 2010 Nov-Dec;31(6):520-3. doi: 10.2500/aap.2010.31.3368.
Urticaria with angioedema is a common clinical presentation that often poses a challenge for allergists. The differential diagnosis for urticaria is broad, making the evaluation and pinpointing the underlying cause difficult and frustrating for both families and physicians. Certain causes of urticaria such as infections or medications are more common and easier to identify whereas less frequently seen conditions are often overlooked because of their rarity. One such condition is mastocytosis. Mastocytosis is a rare disease that very seldom presents with urticaria but may be associated with significant morbidity and mortality if not recognized in a timely manner. We are presenting a case of a 14-year-old boy who presented with urticaria and angioedema possibly caused by a solitary mastocytoma. The learning points from this case are that mastocytosis should be considered in the differential diagnosis of urticaria and solitary mastocytomas may remain active into adolescence, raising concern for systemic progression.
荨麻疹伴血管性水肿是一种常见的临床症状，常给过敏科医生带来挑战。荨麻疹的鉴别诊断范围很广，这使得评估和确定潜在病因对患者及其家属和医生来说都既困难又令人沮丧。某些荨麻疹的病因，如感染或药物，更为常见且更容易识别，而不太常见的病症由于其罕见性而经常被忽视。肥大细胞瘤就是这样一种病症。肥大细胞瘤是一种罕见的疾病，很少表现为荨麻疹，但如果不能及时识别，可能会导致严重的发病率和死亡率。我们报告了一例 14 岁男孩，他因孤立性肥大细胞瘤而出现荨麻疹和血管性水肿。从这个病例中得到的经验教训是，在荨麻疹的鉴别诊断中应考虑肥大细胞瘤，并且孤立性肥大细胞瘤可能会在青春期持续活跃，引起对系统性进展的担忧。
