Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1607-11. doi: 10.1016/j.pnpbp.2011.06.005. Epub 2011 Jun 25.
We have recently reported that spontaneously hypertensive rats (SHR) present a contextual fear conditioning (CFC) deficit. This deficit is improved by antipsychotic drugs, potentiated by proschizophrenia manipulations and not altered by acute administration of carbamazepine, lamotrigine and valproic acid. Nevertheless, the effects of lithium-a classical mood stabilizer-or repeated treatment with these drugs were not evaluated. The main aim of the present study was to extend our previous work by investigating a possible beneficial effect of acute and/or chronic treatments with lithium or lamotrigine on the acquisition deficit of CFC presented by SHR.
Rats were submitted to CFC task after an acute treatment with lithium and/or a repeated treatment with lithium and lamotrigine.
Our data revealed that the CFC deficit presented by SHR is not improved by acute or repeated treatment with lithium. Repeated lamotrigine treatment potentiated the deficit presented by SHR and impaired CFC in control animals (Wistar Rats).
These data reinforce the absence of beneficial effects of mood stabilizers on the emotional context processing impairment modeled by SHR.
我们最近报道了自发性高血压大鼠（SHR）存在情境恐惧条件反射（CFC）缺陷。抗精神病药物可改善这种缺陷，精神分裂症前操作可增强这种缺陷，而卡马西平、拉莫三嗪和丙戊酸的急性给药则不会改变这种缺陷。然而，锂盐——一种经典的心境稳定剂——或这些药物的重复治疗的效果尚未得到评估。本研究的主要目的是通过研究锂盐或拉莫三嗪的急性和/或慢性治疗对 SHR 所呈现的 CFC 获得缺陷的可能有益作用，来扩展我们之前的工作。
大鼠在急性锂盐处理后进行 CFC 任务，以及/或者进行锂盐和拉莫三嗪的重复处理。
我们的数据表明，锂盐的急性或重复治疗并不能改善 SHR 所呈现的 CFC 缺陷。重复拉莫三嗪治疗增强了 SHR 呈现的缺陷，并损害了对照组动物（Wistar 大鼠）的 CFC。
这些数据加强了心境稳定剂对 SHR 模型所呈现的情绪情境处理损伤没有有益作用。
