Staczek J
Department of Microbiology and Immunology, Louisiana State University School of Medicine-Shreveport, Shreveport 71130.
Microbiol Rev. 1990 Sep;54(3):247-65. doi: 10.1128/mr.54.3.247-265.1990.
Cytomegaloviruses are agents that infect a variety of animals. Human cytomegalovirus is associated with infections that may be inapparent or may result in severe body malformation. More recently, human cytomegalovirus infections have been recognized as causing severe complications in immunosuppressed individuals. In other animals, cytomegaloviruses are often associated with infections having relatively mild sequelae. Many of these sequelae parallel symptoms associated with human cytomegalovirus infections. Recent advances in biotechnology have permitted the study of many of the animal cytomegaloviruses in vitro. Consequently, animal cytomegaloviruses can be used as model systems for studying the pathogenesis, immunobiology, and molecular biology of cytomegalovirus-host and cytomegalovirus-cell interactions.
巨细胞病毒是感染多种动物的病原体。人类巨细胞病毒与可能不明显或可能导致严重身体畸形的感染有关。最近，人类巨细胞病毒感染已被认为会在免疫抑制个体中引起严重并发症。在其他动物中，巨细胞病毒通常与具有相对轻微后遗症的感染有关。这些后遗症中的许多与人类巨细胞病毒感染相关的症状相似。生物技术的最新进展使得许多动物巨细胞病毒能够在体外进行研究。因此，动物巨细胞病毒可作为研究巨细胞病毒与宿主以及巨细胞病毒与细胞相互作用的发病机制、免疫生物学和分子生物学的模型系统。
