Ferguson L R, Harris P J, Hollands H J, Roberton A M
Cancer Research Laboratory, University of Auckland, New Zealand.
Mutat Res. 1990 Oct;245(2):111-7. doi: 10.1016/0165-7992(90)90009-9.
The effect of the bile salts, sodium cholate, deoxycholate, glycocholate and taurocholate, on the solubility in aqueous solution of the hydrophobic, environmental mutagen, 1,8-dinitropyrene (DNP), was examined. In the absence of bile salts, the DNP appeared to precipitate out of solution, whereas bile salts at a concentration of greater than or equal to 4 mM maintained the DNP in solution. In the presence of the model dietary fiber, alpha-cellulose, the DNP absorbed to this preferentially. Bile salts reduced this adsorption at low alpha-cellulose levels, but had little effect at high alpha-cellulose levels. The implication of these results is that bile salts have solubilising properties that could affect the distribution of hydrophobic molecules, including mutagens, in the digestive tract.
研究了胆盐（胆酸钠、脱氧胆酸钠、甘氨胆酸钠和牛磺胆酸钠）对疏水性环境诱变剂1,8-二硝基芘（DNP）在水溶液中溶解度的影响。在没有胆盐的情况下，DNP似乎会从溶液中沉淀出来，而浓度大于或等于4 mM的胆盐可使DNP保持在溶液中。在存在模型膳食纤维α-纤维素的情况下，DNP会优先吸附到其上。胆盐在低α-纤维素水平时会减少这种吸附，但在高α-纤维素水平时影响很小。这些结果表明，胆盐具有增溶特性，可能会影响包括诱变剂在内的疏水分子在消化道中的分布。
