Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.
Pharmacology. 2011;88(1-2):10-7. doi: 10.1159/000328772. Epub 2011 Jun 25.
To evaluate the efficacy and safety of 2 analogs of L-carnitine on rats made insulin resistant by a high-fructose diet.
Using rats made insulin resistant by a high-fructose diet, we investigated the impact of 2 analogs of L-carnitine (25 mg/kg) and L-carnitine (250 mg/kg) on glucose, triglycerides and cholesterol blood levels, and liver glycogen. We also evaluated the safety of both analogs by the assessment of some biochemical and hematological parameters, a histological analysis and a study of embryotoxicity.
Both analogs reduced the levels of triglycerides in the liver and plasma, but only analog 2 reduced the cholesterol levels in insulin-resistant rats. No changes were observed in glycogen content. Safety evaluations revealed alterations in blood lymphocytes and embryotoxicity data.
This study demonstrated that the 2 analogs maintain the pharmacological properties of L-carnitine but have a different efficacy, potency and toxicity.
评估 2 种左旋肉碱类似物对果糖饮食诱导胰岛素抵抗大鼠的疗效和安全性。
采用果糖饮食诱导胰岛素抵抗大鼠模型，研究 2 种左旋肉碱类似物（25mg/kg 和 250mg/kg）对血糖、甘油三酯和胆固醇水平以及肝糖原的影响。同时，通过评估一些生化和血液学参数、组织学分析和胚胎毒性研究，评估了这两种类似物的安全性。
两种类似物均降低了肝和血浆中甘油三酯的水平，但只有类似物 2 降低了胰岛素抵抗大鼠的胆固醇水平。肝糖原含量没有变化。安全性评估显示血液淋巴细胞发生变化，并有胚胎毒性数据。
本研究表明，这两种类似物保持了左旋肉碱的药理学特性，但具有不同的疗效、效力和毒性。
