Chalk River Laboratories, Atomic Energy of Canada Limited, Chalk River, Ontario K0J 1J0, Canada.
Health Phys. 2011 Aug;101(2):144-7. doi: 10.1097/HP.0b013e318213d006.
A rapid bioassay method has been developed for the sequential measurements of actinides in human urine samples. The method involves actinide separation from a urine matrix by co-precipitation with hydrous titanium oxide (HTiO), followed by anion exchange and extraction chromatography column purification, and final counting by alpha spectrometry after cerium fluoride micro-precipitation. The minimal detectable activities for the method were determined to be 20 mBq L(-1) or less for plutonium, uranium, americium and curium isotopes, with an 8-h sample turn-around time. Spike tests showed that this method would meet the requirements for actinide bioassay following a radiation emergency.
已开发出一种快速生物分析方法，用于连续测量人尿液样品中的锕系元素。该方法通过与水合氧化钛（HTiO）共沉淀从尿液基质中分离锕系元素，然后通过阴离子交换和萃取色谱柱纯化，最后通过氟化铈微沉淀后进行α谱计数。该方法的最小可检测活度为 20 mBq L(-1)或更低，适用于镎、铀、镅和锔同位素，样品周转时间为 8 小时。加标测试表明，该方法将满足辐射应急后锕系元素生物分析的要求。
