Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, China; Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou, Gansu Province, China.
Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu Province, China; Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou, Gansu Province, China.
Am J Med Sci. 2012 Feb;343(2):155-161. doi: 10.1097/MAJ.0b013e31821f978d.
Autophagy is an intracellular lysosome-dependent catabolic process that is indispensable for maintaining cellular homeostasis through the turnover and elimination of defective or redundant proteins and damaged or aged organelles. Recent studies suggest that autophagy may be closely associated with tumorigenesis and the response of tumor cells to chemotherapeutic drugs. This article reviews recent advances in understanding the molecular mechanisms underlying the regulation of autophagy and the role of autophagy in oncogenesis and anticancer therapy. It is paradoxical that autophagy acts as a mechanism for tumor suppression and contributes to the survival of tumors. In addition, whether autophagy in response to chemotherapies results in cell death or instead protects cancer cells from death is complicated, depending on the nature of the cancer and the drug.
自噬是一种依赖于溶酶体的细胞内降解过程，对于通过周转和消除有缺陷或冗余的蛋白质以及受损或衰老的细胞器来维持细胞内稳态是必不可少的。最近的研究表明，自噬可能与肿瘤发生以及肿瘤细胞对化疗药物的反应密切相关。本文综述了近年来对自噬调控的分子机制以及自噬在肿瘤发生和抗肿瘤治疗中的作用的理解进展。自噬作为一种肿瘤抑制机制，促进肿瘤的存活，这似乎有些矛盾。此外，自噬对化疗的反应是导致细胞死亡还是相反地使癌细胞免于死亡，这很复杂，取决于癌症的性质和药物。
