Thanacoody H K R
Scottish Poisons Information Bureau, Royal Infirmary Edinburgh, 51 Little France Crescent, Edinburgh, UK.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.06.2009.1924. Epub 2009 Jun 26.
A 76-year-old woman being treated with sodium valproate for bipolar depression presented with a 4-day history of acute confusion and tremulousness. She had apnoeic episodes, a reduced conscious level and generalised myoclonic movements. Her plasma valproate concentration was 848 μmol/litre (normal range 300-600 μmol/litre). Administration of naloxone 0.8 mg led to rapid clinical improvement. Naloxone may be useful in reversing the features of chronic valproate toxicity.
一名76岁患有双相抑郁症且正在接受丙戊酸钠治疗的女性，出现了4天的急性意识模糊和震颤病史。她有呼吸暂停发作、意识水平下降和全身性肌阵挛运动。她的血浆丙戊酸浓度为848微摩尔/升（正常范围300 - 600微摩尔/升）。给予0.8毫克纳洛酮后临床症状迅速改善。纳洛酮可能有助于逆转慢性丙戊酸盐中毒的症状。
