Herberg L J, Rose I C
Institute of Neurology, National Hospital, London, England.
Pharmacol Biochem Behav. 1990 Aug;36(4):735-8. doi: 10.1016/0091-3057(90)90069-t.
D-Cycloserine (DCS) binds with high affinity to the glycine site associated with the NMDA receptor in rat brain. Systemic injections of DCS have been reported to facilitate performance on learning tasks, possibly by promoting long-term changes at the NMDA receptor complex. In the present study, DCS failed to affect spontaneous locomotor activity or variable-interval self-stimulation response rate. Cycloleucine, a competitive antagonist of glycine at the glycine site, produced a brief depression of self-stimulation, but only after relatively large doses which were not antagonised by injection of DCS in the dose reported to be optimal for the facilitation of learning. Improvements in learning and retention reported after administration of DCS are therefore unlikely to be accounted for by nonassociative motivational, or performance, factors.
D-环丝氨酸（DCS）与大鼠脑中与N-甲基-D-天冬氨酸（NMDA）受体相关的甘氨酸位点具有高亲和力结合。据报道，全身注射DCS可促进学习任务的表现，可能是通过促进NMDA受体复合物的长期变化。在本研究中，DCS未能影响自发运动活动或可变间隔自我刺激反应率。环亮氨酸是甘氨酸位点上甘氨酸的竞争性拮抗剂，仅在相对大剂量后才会短暂抑制自我刺激，但注射据报道对促进学习最适宜剂量的DCS并不能拮抗这种抑制作用。因此，给予DCS后报告的学习和记忆改善不太可能由非联想性动机或表现因素来解释。
