Schnur P, Walker J M
Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02904.
Pharmacol Biochem Behav. 1990 Aug;36(4):813-6. doi: 10.1016/0091-3057(90)90082-s.
Two experiments investigated the effects of the specific kappa opiate agonist, U50,488 on locomotor activity in the golden Syrian hamster. In Experiment 1, the effects of U50,488 were found to be dose-related, with a 1 mg/kg dose eliciting hyperactivity and a 10 mg/kg dose eliciting hypoactivity. In Experiment 2, the dual effects of U50,488 on locomotor activity were shown to be naloxone (1 mg/kg) reversible. It is suggested that the effects of U50,488 on activity are consistent with the reported dual opposing influences of kappa agonists in the substantia nigra pars compacta and pars reticulata.
两项实验研究了特异性κ阿片受体激动剂U50,488对金黄仓鼠运动活动的影响。在实验1中，发现U50,488的作用与剂量相关，1mg/kg的剂量引起多动，而10mg/kg的剂量引起活动减少。在实验2中，U50,488对运动活动的双重作用被证明可被纳洛酮（1mg/kg）逆转。有人提出，U50,488对活动的作用与已报道的κ激动剂在黑质致密部和网状部的双重相反影响一致。
