Pacák K, Nedvídková J, Stolba P, Schreiber V
Third Medical Department, Faculty of Medicine, Charles University, Prague.
Physiol Bohemoslov. 1990;39(3):249-52.
The authors studied the effect of administration of thyroid hormones on the beta-adrenergic receptors of rat adenohypophyseal cells. The administration of triiodothyronine and thyroxine was followed by an increase in specific binding for 3H-dihydroalprenolol. No significant differences were found in cyclic adenosine monophosphate levels before and after isoprenaline stimulation. The significance of changes in these receptors for the hyperplastic reaction after oestrogens is discussed with reference to the inhibitory effect of the thyroid hormones on hyperplasia of the adenohypophyseal cells after the administration of oestradiol.
作者研究了甲状腺激素给药对大鼠腺垂体细胞β-肾上腺素能受体的影响。给予三碘甲状腺原氨酸和甲状腺素后，3H-二氢阿普洛尔的特异性结合增加。异丙肾上腺素刺激前后环磷酸腺苷水平未发现显著差异。参照甲状腺激素对雌二醇给药后腺垂体细胞增生的抑制作用，讨论了这些受体变化对雌激素后增生反应的意义。
