George D T, Kaye W H, Goldstein D S, Brewerton T D, Jimerson D C
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD.
Psychiatry Res. 1990 Jul;33(1):1-10. doi: 10.1016/0165-1781(90)90143-s.
While abnormalities in central norepinephrine regulation may contribute to abnormal eating patterns in bulimia nervosa, alterations in function of the peripheral sympathetic nervous system could contribute to the decreased metabolic rate and increased anxiety responses previously reported in these patients. To assess beta-adrenergic receptor sensitivity in bulimic patients, we studied cardiovascular and hormonal responses to acute pharmacological challenge with intravenously administered isoproterenol. In comparison to healthy controls, binge-abstinent bulimic patients had significantly reduced mean baseline plasma norepinephrine level, pulse rate, and systolic blood pressure, and significantly increased chronotropic responses to isoproterenol infusion. Decreased sympathoneural activity may contribute to a tendency for bulimic patients to maintain body weight despite low caloric intake.
虽然中枢去甲肾上腺素调节异常可能导致神经性贪食症患者出现异常的饮食模式，但外周交感神经系统功能的改变可能导致这些患者先前报道的代谢率降低和焦虑反应增加。为了评估贪食症患者的β-肾上腺素能受体敏感性，我们研究了静脉注射异丙肾上腺素急性药理刺激后的心血管和激素反应。与健康对照组相比，已戒除暴食行为的贪食症患者的平均基线血浆去甲肾上腺素水平、脉搏率和收缩压显著降低，对异丙肾上腺素输注的变时反应显著增加。交感神经活动降低可能导致贪食症患者尽管热量摄入低但仍有维持体重的倾向。
