Kostyrka B, Li J, Soundappan S V, Cassey J, Alvaro F, Dalla Pozza L, Kumar Rajendra
Department of Paediatric Surgery, John Hunter Children's Hospital, Hunter Region Mail Centre, Newcastle, NSW, Australia.
Pediatr Surg Int. 2011 Sep;27(9):937-41. doi: 10.1007/s00383-011-2937-x. Epub 2011 Jun 28.
Neonatal neuroblastoma (NNBL) is a rare tumour with few reported cases in the literature. The prognosis of NNBL is unclear with reported survival between 76 and 91%. The growing use of ante-natal ultrasound (USS) in recent years has resulted in an increasing incidence of NNBL. The purpose of this study is to review our experience with incidence, clinical features and outcome of NNBL in those children diagnosed ante-natally compared to those diagnosed post-natally.
Twelve cases of NNBL were detected ante-natally or in the neonatal period (0-28 days) from a cohort of 120 children diagnosed with neuroblastoma (10%) over a 10-year period at the study institutions. Review of these 12 children forms the basis of this report.
Ante-natal diagnosis (ADNB) was made in six children (50%) and post-natal diagnosis (PDNB) in six (50%). Tumour site in both cohorts were predominantly adrenal and tumour staging was similar in both groups. There was no difference in outcome in ADNB compared to PDNB with overall 100% survival for the entire group.
NNBL is a subset of neuroblastoma with apparent excellent outcome irrespective of the time of diagnosis. Clinical features and outcomes of ADNB are no different to PDNB.
新生儿神经母细胞瘤（NNBL）是一种罕见肿瘤，文献报道的病例较少。NNBL的预后尚不清楚，报道的生存率在76%至91%之间。近年来产前超声（USS）的使用日益增加，导致NNBL的发病率上升。本研究的目的是回顾我们在产前诊断与产后诊断的儿童中，关于NNBL的发病率、临床特征和预后的经验。
在研究机构为期10年的时间里，从120例被诊断为神经母细胞瘤的儿童（10%）队列中，产前或新生儿期（0 - 28天）检测到12例NNBL。对这12名儿童的回顾构成了本报告的基础。
6名儿童（50%）为产前诊断（ADNB），6名（50%）为产后诊断（PDNB）。两组的肿瘤部位主要为肾上腺，且两组的肿瘤分期相似。与PDNB相比，ADNB的预后无差异，整个组的总生存率为100%。
NNBL是神经母细胞瘤的一个亚型，无论诊断时间如何，预后明显良好。ADNB的临床特征和预后与PDNB无差异。
