Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino-University of Genoa, Genoa, Italy.
Am J Rhinol Allergy. 2011 Jan-Feb;25(1):e30-3. doi: 10.2500/ajra.2011.25.3578.
Allergic rhinitis (AR) may be frequently associated with asthma or precede it. Bronchial involvement in AR is usually detected by spirometry. Forced expiratory volume in 1 second (FEV(1)) is considered a reliable parameter for asthma diagnosis. However, forced expiratory flow at 25-75% (FEF(25-75)) could be considered a possible marker of early bronchial involvement in AR; indeed, it has been proposed that FEF(25-75) values <70% of predicted may predict this evolution. The aim of this study was to evaluate a large cohort of children with AR to define an FEV(1) value corresponding to impaired FEF(25-75) values.
Eight hundred fifty AR children (555 boys; median age, 10 years) were studied. Spirometry and skin-prick test were performed in all of them. Descriptive statistic and multivariate analysis were considered.
Three-hundred (35.3%) patients had FEF(25-75) values <70% of predicted. Still, normal FEV(1) values were associated with overt impaired FEF(25-75) values and the cutoff value was 83%.
Spirometry should be adequately interpreted in AR patients; indeed, an FEV(1) cutoff value of 83% detects with good efficiency AR children with early bronchial impairment.
过敏性鼻炎（AR）可能经常与哮喘相关，或者先于哮喘发生。支气管在 AR 中的受累通常通过肺活量测定法来检测。第 1 秒用力呼气量（FEV1）被认为是哮喘诊断的可靠参数。然而，在 25%-75%用力呼气量（FEF25-75）可能被认为是 AR 早期支气管受累的一个可能标志物；实际上，有人提出 FEF25-75 值<70%预计值可能预示着这种演变。本研究旨在评估一大群 AR 患儿，以确定与 FEF25-75 受损值相对应的 FEV1 值。
对 855 名 AR 儿童（555 名男孩；中位数年龄 10 岁）进行了研究。所有患儿均进行了肺活量测定和皮肤点刺试验。考虑了描述性统计和多元分析。
300 名（35.3%）患儿的 FEF25-75 值<70%预计值。然而，仍有明显的 FEV1 值与明显受损的 FEF25-75 值相关，其截断值为 83%。
在 AR 患者中应充分解读肺活量测定结果；实际上，FEV1 截断值为 83%可有效地检测出早期支气管受损的 AR 患儿。
