Maddison Ben, Parsons Amy, Sangueza Omar, Sheehan Daniel J, Yosipovitch Gil
Colworth Discover, Colworth Science Park, Sharnbrook, Bedfordshire, United Kingdom.
Am J Dermatopathol. 2011 Aug;33(6):621-3. doi: 10.1097/DAD.0b013e3181fe4c3c.
Nummular eczema is a chronic inflammatory condition characterized by pruritus and histologically characterized by spongiosis. The etiology is unknown, and the lesions frequently arise spontaneously. Neuropeptides contribute to mediating and maintaining eczematous conditions. Previous research indicates that the number of immunoreactive nerve fibers is increased in pruritic skin lesions.
We sought to determine if the number of immunoreactive nerve fibers is increased in nummular eczema, as in other inflammatory pruritic conditions.
Protein gene product 9.5 (PGP 9.5) was assessed by immunohistochemistry in 22 biopsies of nummular eczema and was compared with immunohistochemical expression of 8 skin biopsies uninvolved by nummular eczema.
Nerve fiber distribution using PGP 9.5 stain showed that there was significantly reduced PGP9.5 stain amount in the epidermis of patients with nummular eczema compared with their respective healthy control (P = 0.0054). However, no statistical difference was seen in the papillary dermis.
Pruritus of nummular eczema is not associated with an increase of epidermal nerve fiber density and sprouting.
钱币状湿疹是一种慢性炎症性疾病，其特征为瘙痒，组织学表现为海绵形成。病因不明，皮损常自发出现。神经肽有助于介导和维持湿疹状态。先前的研究表明，瘙痒性皮肤损害中免疫反应性神经纤维数量增加。
我们试图确定钱币状湿疹中免疫反应性神经纤维数量是否如其他炎症性瘙痒性疾病一样增加。
通过免疫组织化学方法对22例钱币状湿疹活检标本中的蛋白基因产物9.5（PGP 9.5）进行评估，并与8例未患钱币状湿疹的皮肤活检标本的免疫组化表达进行比较。
使用PGP 9.5染色的神经纤维分布显示，钱币状湿疹患者表皮中的PGP9.5染色量与其各自的健康对照相比显著减少（P = 0.0054）。然而，在乳头真皮层未见统计学差异。
钱币状湿疹的瘙痒与表皮神经纤维密度增加和神经纤维芽生无关。
