Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Platelets. 2011;22(5):380-4. doi: 10.3109/09537104.2011.556274. Epub 2011 Jun 30.
The c-type lectin-like receptor 2 (CLEC-2) was first identified from a bio-informatic screen for c-type lectin-like receptors. However, neither its function nor its ligand(s) had been elucidated for several years. In 2006, we reported that the receptor is expressed on the surface of platelets and serves as a receptor for the snake venom rhodocytin, which potently stimulates platelet aggregation. Since then CLEC-2 has been intensively investigated, and its endogenous/exogenous ligands and several physiological/pathological roles have been clarified. In this article and its accompanying poster, we outline the structure, distribution, signal transduction mechanism and functions of CLEC-2.
C 型凝集素样受体 2（CLEC-2）最初是从 C 型凝集素样受体的生物信息学筛选中鉴定出来的。然而，其功能及其配体（s）多年来一直没有得到阐明。2006 年，我们报道该受体表达在血小板表面，作为蛇毒 rhodocytin 的受体，其强烈刺激血小板聚集。自那时以来，CLEC-2 已被深入研究，其内源性/外源性配体及其几种生理/病理作用已得到阐明。在本文及其配套海报中，我们概述了 CLEC-2 的结构、分布、信号转导机制和功能。
