Schwarz T F, Nerlich A, Roggendorf M
Max v. Pettenkofer-Institute for Hygiene and Medical Microbiology, Ludwig-Maximilians-University Munich, W. Germany.
Behring Inst Mitt. 1990 Aug(85):69-73.
Parvovirus B19 infection in pregnancy can cause hydrops fetalis resulting in fetal loss. Acute B19 infection was serologically confirmed in 80 pregnant women by ELISA. Of 80 pregnancies, 4 were terminated. Of the remaining 76 pregnancies, no fetal complications were observed in 36 (47.4%), hydrops fetalis occurred in 18 (23.7%) and no further information was available in 22 (28.9%). 15 of 18 (83.3%) fetuses with hydrops died. Intrauterine transfusion was performed in the remaining three fetuses and pregnancy continued without further complications. B19 infected fetal erythroblasts can be detected by standard histological staining methods and in situ hybridisation using a digoxigenin-labelled B19 DNA probe. Non-immune pregnant females working in kindergartens or schools should be suspended during an epidemic outbreak of B19 in such institutions.
孕期感染细小病毒B19可导致胎儿水肿，进而造成流产。通过酶联免疫吸附测定法（ELISA）对80名孕妇进行血清学检测，确诊为急性B19感染。这80例妊娠中，4例终止妊娠。其余76例妊娠中，36例（47.4%）未观察到胎儿并发症，18例（23.7%）出现胎儿水肿，22例（28.9%）无更多信息。18例水肿胎儿中有15例（83.3%）死亡。对其余3例胎儿进行了宫内输血，妊娠继续，未出现进一步并发症。采用地高辛标记的B19 DNA探针，通过标准组织学染色方法和原位杂交可检测出B19感染的胎儿成红细胞。在幼儿园或学校发生B19疫情期间，在这类机构工作的非免疫孕妇应暂停工作。
