SPECT LAB: Nuclear Medicine Services, Pune, India.
Clin Nucl Med. 2011 Aug;36(8):e81-6. doi: 10.1097/RLU.0b013e31821c99b2.
Pyrexia of unknown origin (PUO) is defined as fever above 38.5°C lasting for 3 weeks, of which at least 1 week has been spent in thorough investigation without a conclusive cause. Tuberculosis remains an important cause of PUO, particularly with the rising incidence of human immunodeficiency virus infection. It may strike virtually any organ in the body and can even mimic metastases especially in a known treated case of carcinoma. Bacterial infections, human immunodeficiency virus, hidden malignancy, sarcoidosis, and autoimmune disorders are some other important causes of PUO. Initial investigations include examination of blood, urine, stool, blood biochemistry, culture, etc. Typical radiologic investigations include chest radiography, computed tomography, and magnetic resonance imaging. Presented here is an atlas of cases where these investigations had been inconclusive but fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography demonstrated the site of pathology and directed histologic diagnosis.
不明原因发热（PUO）定义为体温高于 38.5°C，持续 3 周，其中至少有 1 周进行了彻底的调查，但仍未找到明确的病因。结核病仍然是 PUO 的一个重要原因，特别是在人类免疫缺陷病毒感染发病率上升的情况下。它几乎可以侵袭身体的任何器官，甚至可以模仿转移，特别是在已知治疗过的癌病例中。细菌感染、人类免疫缺陷病毒、隐匿性恶性肿瘤、结节病和自身免疫性疾病是其他一些导致 PUO 的重要原因。初步检查包括血液、尿液、粪便、血液生化、培养等检查。典型的影像学检查包括胸部 X 线摄影、计算机断层扫描和磁共振成像。这里介绍了一系列病例，这些病例的检查结果均不明确，但氟-18 氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描显示了病变部位，并指导了组织学诊断。
