Martin Tracey A, Jiang Wen G
Metastasis & Angiogenesis Research Group, University Department of Surgery, Cardiff School of Medicine, Cardiff University, Cardiff, UK.
Methods Mol Biol. 2011;762:383-407. doi: 10.1007/978-1-61779-185-7_28.
Metastatic spread of cancer is the major reason for patient mortality in human breast cancer. We examined expression of claudin-16 in human breast cells and tissues to identify a possible link between expression and aggressiveness in cells and between claudin-16 levels and patient prognosis. Forced expression of claudin-16 in breast cancer cells resulted in a less aggressive phenotype and reduced in vivo tumour volume. Claudin-16 expression was reduced in human breast cancer, particularly in patients with aggressive tumours and high mortality (Martin et al. J Cell Biochem 105:41-52,2008). This suggests that claudin-16 plays a role beyond that of an initial metastasis repressor in this cancer type.
癌症的转移扩散是人类乳腺癌患者死亡的主要原因。我们检测了claudin-16在人乳腺细胞和组织中的表达，以确定其表达与细胞侵袭性之间以及claudin-16水平与患者预后之间的可能联系。在乳腺癌细胞中强制表达claudin-16会导致侵袭性较低的表型，并减小体内肿瘤体积。在人类乳腺癌中，claudin-16的表达降低，尤其是在患有侵袭性肿瘤和高死亡率的患者中（Martin等人，《细胞生物化学杂志》105:41-52，2008年）。这表明claudin-16在这种癌症类型中所起的作用超出了最初转移抑制因子的作用。
