Kataoka M, Kawamura M, Ueda N, Itoh H, Iio A, Hamamoto K
Department of Radiology, Ehime University School of Medicine, Onsen-gun, Japan.
Clin Nucl Med. 1990 Oct;15(10):707-11.
To evaluate the clinical usefulness of Ga-67 imaging for the assessment of radiation pneumonitis, 12 patients who had developed radiation pneumonitis after receiving radiotherapy alone for non-small-cell lung cancer from 1979 through 1988 were reviewed. Diffuse bilateral Ga-67 uptake occurred in 5 out of the 12 cases; in the other 7 cases, Ga-67 uptake was confined to the irradiation lung. Conversely, chest radiography showed infiltrates only in the irradiated lung. Histopathology of the lung in four out of the five cases that showed diffuse Ga-67 uptake in the lung, however, revealed that the lung outside the radiation field with Ga-67 uptake was consistent with interstitial pneumonitis induced by radiation. These results suggest that radiation pneumonitis could extend beyond the irradiated lung and that Ga-67 imaging is more useful than chest radiography for the assessment of the spatial extent of radiography pneumonitis.
为评估镓-67显像在放射性肺炎评估中的临床实用性，我们回顾了1979年至1988年间因非小细胞肺癌仅接受放射治疗后发生放射性肺炎的12例患者。12例中有5例出现双侧弥漫性镓-67摄取；其他7例中，镓-67摄取局限于受照射肺。相反，胸部X线片仅显示受照射肺有浸润。然而，在肺部显示弥漫性镓-67摄取的5例中的4例肺组织病理学检查显示，有镓-67摄取的放射野外肺组织与放射性诱导的间质性肺炎一致。这些结果表明，放射性肺炎可能超出受照射肺，并且镓-67显像在评估放射性肺炎的空间范围方面比胸部X线片更有用。
