Kashleva E A, Matveeva V A, Uvarova E N, Kliuchareva T E
Eksp Onkol. 1990;12(5):32-4.
Seven clonal sublines of the strain of syrian hamster embryo cells transformed in vitro by the Rous sarcoma virus were obtained. All clones possessed both high resistance to damage by hydrogen peroxide and a capacity to release E-type prostaglandins in response to contact with NK-cells in vitro. The clones did not differ from each other and from the parent population in respect to these qualitative properties. Possible relation between these two properties and their role in resistance of transformed cells to cytotoxic activity of macrophages, neutrophils and NK-cells and thus to their ability to survive in vivo are discussed.
获得了由劳斯肉瘤病毒体外转化的叙利亚仓鼠胚胎细胞株的七个克隆亚系。所有克隆都对过氧化氢损伤具有高度抗性，并且在体外与自然杀伤细胞接触时能够释放E型前列腺素。就这些定性特性而言，这些克隆彼此之间以及与亲代群体之间没有差异。讨论了这两种特性之间可能的关系，以及它们在转化细胞对巨噬细胞、中性粒细胞和自然杀伤细胞的细胞毒活性的抗性中的作用，进而在其体内存活能力中的作用。
