Department of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.
Plant Cell. 2011 Jun;23(6):2033-43. doi: 10.1105/tpc.111.087064. Epub 2011 Jun 30.
AUXIN BINDING PROTEIN1 (ABP1) is one of the first characterized proteins that bind auxin and has been implied as a receptor for a number of auxin responses. Early studies characterized its auxin binding properties and focused on rapid electrophysiological and cell expansion responses, while subsequent work indicated a role in cell cycle and cell division control. Very recently, ABP1 has been ascribed a role in modulating endocytic events at the plasma membrane and RHO OF PLANTS-mediated cytoskeletal rearrangements during asymmetric cell expansion. The exact molecular function of ABP1 is still unresolved, but its main activity apparently lies in influencing events at the plasma membrane. This review aims to connect the novel findings with the more classical literature on ABP1 and to point out the many open questions that still separate us from a comprehensive model of ABP1 action, almost 40 years after the first reports of its existence.
生长素结合蛋白 1（ABP1）是首批被鉴定出能结合生长素的蛋白之一，并且被认为是许多生长素反应的受体。早期研究描述了其生长素结合特性，并侧重于快速电生理学和细胞扩展反应，而随后的工作表明其在细胞周期和细胞分裂控制中发挥作用。最近，ABP1 被赋予了在调节质膜内吞事件以及 RHO 植物介导的不对称细胞扩展期间细胞骨架重排中的作用。ABP1 的确切分子功能仍未解决，但它的主要活性显然在于影响质膜上的事件。本综述旨在将新发现与关于 ABP1 的更经典文献联系起来，并指出在首次报道其存在近 40 年后，仍有许多悬而未决的问题将我们与 ABP1 作用的综合模型分隔开来。
