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[烟雾病患者术后脑过度灌注致严格血压控制下的无症状性脑出血]

[Asymptomatic intracerebral hemorrhage under strict blood pressure control due to postoperative cerebral hyperperfusion in a patient with moyamoya disease].

作者信息

Ito Akira, Fujimura Miki, Inoue Takashi, Tominaga Teiji

机构信息

Department of Neurosurgery, Kohnan Hospital, Japan.

出版信息

No Shinkei Geka. 2011 Jul;39(7):681-6.

PMID:21719912
Abstract

We report a case of moyamoya disease manifesting as asymptomatic intracerebral hemorrhage due to postoperative cerebral hyperperfusion, despite the prophylactic intensive blood pressure control. This 35-year-old man initially suffered from right upper quadrantanopsia and was found to have cerebral infarction in the left occipital lobe due to moyamoya disease. He also manifested preoperatively a small intracerebral hemorrhage at the left caudate nucleus. The left cerebral hemisphere showed apparent hemodynamic compromise, thus he underwent left superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis with indirect pial synangiosis. He was subjected to prophylactic strict blood pressure control postoperatively to avoid hyperperfusion syndrome. The N-isopropyl-p-I-Iodoamphetamine SPECT (I-IMP-SPECT) 1 day after surgery showed intense increase in cerebral blood flow (CBF) at the site of the anastomosis, and further blood pressure lowering was attempted. He did not suffer from neurologic deterioration during the postoperative period, while computed tomography (CT) 7 days after surgery revealed asymptomatic intracerebral hematoma (ICH) at the subcortex under the site of the anastomosis. Cerebral hyperperfusion is a potential complication of revascularization surgery for moyamoya disease. Accurate diagnosis and proper management of hyperperfusion are essential to avoid deleterious neurologic event due to hyperperfusion.

摘要

我们报告一例烟雾病患者,尽管进行了预防性强化血压控制,但术后仍因脑过度灌注出现无症状性脑出血。这名35岁男性最初患有右上象限偏盲,经检查发现因烟雾病导致左枕叶脑梗死。术前他还在左侧尾状核出现少量脑出血。左侧大脑半球显示出明显的血流动力学受损,因此他接受了左颞浅动脉-大脑中动脉(STA-MCA)吻合术及间接软膜血管吻合术。术后对他进行了预防性严格血压控制,以避免过度灌注综合征。术后1天的N-异丙基-p-碘安非他明单光子发射计算机断层扫描(I-IMP-SPECT)显示吻合部位脑血流量(CBF)急剧增加,并尝试进一步降低血压。术后他未出现神经功能恶化,但术后7天的计算机断层扫描(CT)显示吻合部位下方皮质下出现无症状性脑内血肿(ICH)。脑过度灌注是烟雾病血运重建手术的一种潜在并发症。准确诊断和妥善处理过度灌注对于避免因过度灌注导致的有害神经事件至关重要。

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引用本文的文献

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Progress on Complications of Direct Bypass for Moyamoya Disease.烟雾病直接搭桥术并发症的研究进展
Int J Med Sci. 2016 Jul 5;13(8):578-87. doi: 10.7150/ijms.15390. eCollection 2016.
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Common features in patients with intracerebral hemorrhage following superficial temporal artery-middle cerebral artery bypass in steno-occlusive cerebrovascular disease.狭窄闭塞性脑血管疾病行颞浅动脉-大脑中动脉搭桥术后脑出血患者的共同特征
Neural Regen Res. 2012 Jul 15;7(20):1585-90. doi: 10.3969/j.issn.1673-5374.2012.20.009.