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Evidence for communication between nerve growth factor and protein tyrosine phosphorylation.

作者信息

Gómez N, Tonks N K, Morrison C, Harmar T, Cohen P

机构信息

Department of Biochemistry, University of Dundee, UK.

出版信息

FEBS Lett. 1990 Oct 1;271(1-2):119-22. doi: 10.1016/0014-5793(90)80386-w.

DOI:10.1016/0014-5793(90)80386-w
PMID:2171996
Abstract

Nerve growth factor (NGF) stimulation of PC12 cells activated two myelin basic protein (MBP) kinase activities greater than 10-fold within 5 min, which were resolved by chromatography on Mono Q. Each enzyme phosphorylated MBP on threonine and was inactivated by incubation with either CD45, a protein tyrosine phosphatase, or protein phosphatase 2A (PP2A), a serine/threonine phosphatase. The effects of CD45 and PP2A were prevented by vanadate and okadaic acid, respectively. Activation of the MBP-kinases provides a mechanism for communication between NGF and intracellular protein tyrosine phosphorylation.

摘要

相似文献

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Evidence for communication between nerve growth factor and protein tyrosine phosphorylation.
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