Nonaka Kiichi, Uchiyama Shigeharu
ELK Corporation, Musculoskeletal System Group.
Clin Calcium. 2011 Jul;21(7):1003-9.
It is one of the most important challenges for preventing hip fractures to establish an accurate non-invasive assessment of hip fracture risk. Quantitative computed tomography (QCT) is able to analyze not only volumetric bone mineral density (mg/cm3) of trabecular and cortical bone compartment separately, but also geometry and biomechanical parameters in bone such as cross-sectional area, cortical bone thickness, section modulus, buckling ratio etc. The analysis of geometry and biomechanical parameters at hip could provide better prediction of hip fracture risk, better understanding pathogenesis of hip fractures, and thus better selection of drug and/or lifestyle-based interventions.
建立准确的髋部骨折风险无创评估是预防髋部骨折最重要的挑战之一。定量计算机断层扫描（QCT）不仅能够分别分析小梁骨和皮质骨区域的体积骨密度（mg/cm³），还能分析骨骼的几何和生物力学参数，如横截面积、皮质骨厚度、截面模量、屈曲比等。对髋部几何和生物力学参数的分析可以更好地预测髋部骨折风险，更好地理解髋部骨折的发病机制，从而更好地选择基于药物和/或生活方式的干预措施。
