Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Horm Res Paediatr. 2011;76(2):130-5. doi: 10.1159/000328055. Epub 2011 Jun 29.
BACKGROUND/AIMS: Boys with constitutional delay of growth and puberty (CDGP) with early reduction in relative height before the onset of puberty will have adult height (AH) clearly below their target height (TH). Characteristics of growth in girls with CDGP are poorly known. We examined whether girls with CDGP attain their TH and whether early reduction in height SDS influences their AH. We also investigated effects of low-dose estrogen on AH.
We investigated growth of 39 women (7 treated with low-dose estrogen) with CDGP history. We compared AH between estrogen-treated and untreated subjects, and used multiple linear regression to investigate the influence of various growth characteristics, e.g. height SDS changes between different ages in childhood, on AH.
AH was similar in estrogen-treated and untreated subjects. Reduction of height SDS between 3 and 8 years was significantly associated with the difference between AH and TH (regression coefficient 0.8, 95% confidence interval 0.1-1.5). Overall, 49% of subjects had AH >0.50 SDS below TH.
A proportion of CDGP girls do not attain AH consistent with their TH. Reduction in height SDS in childhood predicts smaller AH. Low-dose estrogen treatment does not seem to influence AH in girls with CDGP.
背景/目的：具有生长和青春期发育迟缓的男孩（CDGP）在青春期前相对身高提前下降，其成人身高（AH）明显低于目标身高（TH）。CDGP 女孩的生长特征知之甚少。我们检查了 CDGP 女孩是否达到了她们的 TH，以及身高 SDS 的早期下降是否影响了她们的 AH。我们还研究了低剂量雌激素对 AH 的影响。
我们调查了 39 名具有 CDGP 病史的女性（7 名接受低剂量雌激素治疗）的生长情况。我们比较了雌激素治疗和未治疗组的 AH，并使用多元线性回归来研究各种生长特征（例如，儿童期不同年龄之间的身高 SDS 变化）对 AH 的影响。
雌激素治疗和未治疗组的 AH 相似。3 至 8 岁之间身高 SDS 的下降与 AH 和 TH 之间的差异显著相关（回归系数 0.8，95%置信区间 0.1-1.5）。总体而言，49%的受试者的 AH 低于 TH，SDS 为 0.50。
一部分 CDGP 女孩的 AH 与 TH 不一致。儿童时期身高 SDS 的下降预测 AH 较小。低剂量雌激素治疗似乎不会影响 CDGP 女孩的 AH。
