Korot'ko G F, Khudoiarova A G
Fiziol Zh SSSR Im I M Sechenova. 1990 Jun;76(6):770-7.
Stimulation of mechanoreceptors of pancreatic main duct's distal portion activated secretion of bicarbonates and depressed secretion of protein, including enzymes, in dogs. Their incretion is increased, at that. The action of novocain on the duct either decreased or abolished the effect of activation and depression of secretion of various types of pancreocytes: the producers of bicarbonates and enzymes. The pancreas secretion from its two ducts was studied, too. Their secret differed by amylo- and lipolytic activity. An increased of the pressure in the main duct was found both to alter the secretion in the area drained through a given duct and to affect the properties of the secret drained through additional duct. The 10 or 15 cm H2O pressure increased the secretion debit of amylase, lipase and proteinase whereas a higher pressure suppressed their secretion. Several contours of the pancreatic secretion self-regulation seem to exist including one spreading from the gland duct system to its glandulocytes. Probable mechanisms of this self-regulation are discussed.
刺激犬胰腺主导管远端的机械感受器可激活碳酸氢盐分泌，并抑制蛋白质（包括酶）的分泌。此时，它们的分泌增加。奴夫卡因对导管的作用可降低或消除激活和抑制各类胰腺细胞（碳酸氢盐和酶的产生细胞）分泌的效应。还研究了胰腺两条导管的分泌情况。它们的分泌物在淀粉分解和脂肪分解活性方面存在差异。发现主导管压力升高既会改变通过特定导管引流区域的分泌，也会影响通过其他导管引流的分泌物的性质。10或15厘米水柱的压力会增加淀粉酶、脂肪酶和蛋白酶的分泌量，而更高的压力则会抑制它们的分泌。胰腺分泌的自我调节似乎存在多种途径，包括从腺导管系统延伸至腺细胞的一种途径。本文讨论了这种自我调节的可能机制。
