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[影响噬菌体Mu侵入大肠杆菌K-12细胞的突变体pfm的分离与特性]

[Isolation and characteristics of mutation pfm affecting the penetration of phage Mu into Escherichia coli K-12 cells].

作者信息

Oskolkova O B, Piruzian E S

出版信息

Genetika. 1990 Jun;26(6):1000-7.

PMID:2172078
Abstract

A mutant of Escherichia coli K-12 strain with the destroyed process of establishment of lysogenic state for phage Mu in the course of zygotic induction has been obtained. The mutation revealed, designated pfm (penetration factor for Mu), interferes with adsorption of phage Mu to the surface of E. coli K-12 cells. On the basis of data obtained, there is every reason to believe that the phage Mu DNA connection with the membrane components of the bacterial cell provides optimizing condition for the primary integrative transposition of phage Mu at the stage of Mu DNA introduction into the cell.

摘要

已获得一株大肠杆菌K-12菌株的突变体,该突变体在合子诱导过程中破坏了噬菌体Mu溶原状态的建立过程。所发现的这种突变,命名为pfm(Mu的穿透因子),会干扰噬菌体Mu吸附到大肠杆菌K-12细胞表面。根据所获得的数据,完全有理由相信,噬菌体Mu DNA与细菌细胞膜成分的连接为噬菌体Mu DNA导入细胞阶段的初次整合转座提供了优化条件。

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