Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Ann Nucl Med. 2011 Oct;25(8):529-35. doi: 10.1007/s12149-011-0505-z. Epub 2011 Jul 1.
Radionuclides of rare earth elements are gaining importance as emerging therapeutic agents in nuclear medicine. β(-)-particle emitter 142Pr [T (1/2) = 19.12 h, E(-)β = 2.162 MeV (96.3%), Eγ = 1575 keV (3.7%)] is one of the praseodymium-141 (100% abundant) radioisotopes. Production routes and therapy aspects of 142Pr will be reviewed in this paper. However, 142Pr produces via 141Pr(n, γ) 142Pr reaction by irradiation in a low-fluence reactor; 142Pr cyclotron produced, could be achievable. 142Pr due to its high β(-)-emission and low specific gamma γ-emission could not only be a therapeutic radionuclide, but also a suitable radionuclide in order for biodistribution studies. Internal radiotherapy using 142Pr can be classified into two sub-categories: (1) unsealed source therapy (UST), (2) brachytherapy. UST via 142Pr-HA and 142Pr-DTPA in order for radiosynovectomy have been proposed. In addition, 142Pr Glass seeds and 142Pr microspheres have been utilized for interstitial brachytherapy of prostate cancer and intraarterial brachytherapy of arteriovenous malformation, respectively.
稀土元素的放射性核素作为核医学中的新兴治疗剂越来越受到重视。β(-)粒子发射体 142Pr [T (1/2) = 19.12 h, E(-)β = 2.162 MeV (96.3%), Eγ = 1575 keV (3.7%)] 是镨-141 (100%丰度) 的放射性同位素之一。本文将回顾 142Pr 的生产途径和治疗方面。然而，142Pr 可通过在低通量反应堆中辐照 141Pr(n, γ) 142Pr 反应产生；142Pr 回旋加速器产生，也有可能实现。142Pr 由于其高 β(-)发射和低特定γγ发射，不仅可以作为治疗性放射性核素，而且还可以作为生物分布研究的合适放射性核素。使用 142Pr 的内部放射治疗可分为两类：(1) 非密封源治疗 (UST)，(2) 近距离放射治疗。已经提出了 142Pr-HA 和 142Pr-DTPA 用于放射性滑膜切除术的 UST。此外，142Pr 玻璃种子和 142Pr 微球分别用于前列腺癌的间质近距离放射治疗和动静脉畸形的动脉内近距离放射治疗。
