Alonso-Navarro Hortensia, Jiménez-Jiménez Félix J, Plaza-Nieto José F, Pilo-De la Fuente Belén, Navacerrada Francisco, Arroyo-Solera Margarita, Calleja Marisol
Departamento de Medicina-Neurología, Hospital Príncipe deAsturias, Universidad de Alcalá;Alcalá de Henares, Madrid.
Rev Neurol. 2011 Jul 16;53(2):73-6.
The possible usefulness of botulinum toxin type A in the treatment of bruxism has not been studied exhaustively, being limited to some isolated case reports, two short case-series and a double-blind study involving a small number or patients. This article report our long-term experience in the treatment of bruxism with botulinum toxin type A.
The outcome of 19 patients with severe bruxism who underwent periodical treatment with botulinum toxin A infiltrations in both temporal and masseter muscles, using initial doses of 25 IU per muscle, during a follow-up period ranging from 0.5 to 11 years, is described. Doses were adjusted in follow-up visits according the response degree.
None of the patients reported side-effects. Final doses ranged from 25 to 40 IU per muscle (mean: 29.7 ± 4.9 UI), and duration of the effect from 13 to 26 weeks (mean: 16.7 ± 5.1 weeks).
Botulinum toxin A infiltrations are a safe and useful treatment for patients with severe bruxism.
A型肉毒杆菌毒素在磨牙症治疗中的潜在效用尚未得到详尽研究，目前仅限于一些孤立的病例报告、两个简短的病例系列以及一项涉及少数患者的双盲研究。本文报告了我们使用A型肉毒杆菌毒素治疗磨牙症的长期经验。
描述了19例重度磨牙症患者的治疗结果，这些患者在0.5至11年的随访期内，接受了颞肌和咬肌注射A型肉毒杆菌毒素的定期治疗，初始剂量为每块肌肉25国际单位。在随访期间，根据反应程度调整剂量。
所有患者均未报告副作用。最终剂量为每块肌肉25至40国际单位（平均：29.7±4.9国际单位），效果持续时间为13至26周（平均：16.7±5.1周）。
A型肉毒杆菌毒素注射对重度磨牙症患者是一种安全有效的治疗方法。
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