Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.
J Mass Spectrom. 2011 Jul;46(7):672-6. doi: 10.1002/jms.1937.
The auto-resonant trap mass spectrometer, ART-MS, utilizes electrostatic ion trapping within an anharmonic potential well. Ions are detected after mass selective trap ejection with auto-resonant driving employing only low-power rf electronics. We identify the major limiting factor in the mass resolution of these instruments. Whilst keeping in the spirit of maintaining a rapid scan rate, low cost, lightweight instrument, with minimal required machining tolerances, we introduce a method for much improving the mass resolutions of an ART-MS. The addition of two electrodes has enabled an improvement in the mass resolution by a factor of ∼4. The scheme significantly reduces the effects of a finite sized trap and compensates for the influence of radial variation in natural oscillating frequencies within the trap. Compensation can be implemented with a wide range of designs and is not limited by the size of the trap.
自动共振陷阱质谱仪（ART-MS）利用非谐电势阱中的静电离子捕获。采用仅使用低功率射频电子学的自动共振驱动进行质量选择阱弹出后，即可检测到离子。我们确定了这些仪器的质量分辨率的主要限制因素。在保持快速扫描速率、低成本、轻量级仪器以及最小加工公差的精神的同时，我们引入了一种方法，可以大大提高 ART-MS 的质量分辨率。通过添加两个电极，质量分辨率提高了约 4 倍。该方案显著降低了有限尺寸阱的影响，并补偿了阱内自然振荡频率径向变化的影响。补偿可以通过多种设计来实现，并且不受阱尺寸的限制。
