外源性前列腺素E1对人血浆去甲肾上腺素水平及多巴胺-β-羟化酶活性的影响。
Effects of exogenous prostaglandin E1 on human plasma norepinephrine level and dopamine-beta-hydrolyxase activity.
作者信息
Ogawa K, Ito T, Ban M, Matsuno T, Shiozu H, Tsutiya S, Enomoto K
出版信息
Acta Biol Med Ger. 1978;37(5-6):845-8.
Effects of exogenous PG E1 on the level of human plasma norepinephrine (NE), dopamine-beta-hydroxylase (DBH) activity, cAMP, cGMP, free fatty acids (FFA) as well as pulse rate and blood pressure were studied. Significant decreases of blood pressure and increases of pulse rate were observed after 20 min of the infusion of 0.05 microgram/kg/min of PG E1. The level of plasma NE increased by 174% (p less than 0.005) after the infusion. However, the increase of DBH activity was not significant. There was a tendency of increase of plasma level of FFA. These results suggested that the infusion of PG E1 caused an augmented sympathetic nervous activity due to systemic hypotension induced by PG E1.
研究了外源性前列腺素E1对人血浆去甲肾上腺素（NE）水平、多巴胺-β-羟化酶（DBH）活性、环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）、游离脂肪酸（FFA）以及脉搏率和血压的影响。输注0.05微克/千克/分钟的前列腺素E1 20分钟后，观察到血压显著下降，脉搏率增加。输注后血浆NE水平升高了174%（p<0.005）。然而，DBH活性的增加并不显著。血浆FFA水平有升高的趋势。这些结果表明，输注前列腺素E1由于其诱导的全身性低血压导致交感神经活动增强。
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