Department of Hematological, Pneumological and Cardiovascular Sciences, Section of Pneumology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Biointerphases. 2011 Jun;6(2):P1-17. doi: 10.1116/1.3582324.
Carbon nanotubes are molecular-scale one-dimensional manufactured materials which display several potential applications in engineering and materials science. Burgeoning evidence demonstrates that carbon nanotubes and asbestos share comparable physical properties. Therefore carbon nanotubes might display toxic effects and the extent of the toxicity is more specifically directed to lung and pleura. These effects are related to properties of carbon nanotubes, such as their structure, length, aspects ratio, surface area, degree of aggregation, extent of oxidation, bound functional group, method of manufacturing, concentration and dose. At the present there is no global agreement about the risk of carbon nanotubes on human health and in particular on their transformation capacity. Safety concerns regarding carbon nanotubes can be ameliorated. In this context, it is important to put the known hazards of carbon nanotubes into perspective. Here is presented an overview about toxicity issues in the application of carbon nanotubes to biological systems, taking into consideration the already known asbestos-induced mechanisms of biological damages.
碳纳米管是分子尺度的一维人工材料，在工程和材料科学中有多种潜在的应用。越来越多的证据表明，碳纳米管和石棉具有相似的物理性质。因此，碳纳米管可能会显示出毒性作用，其毒性程度更具体地指向肺和胸膜。这些影响与碳纳米管的性质有关，如结构、长度、纵横比、表面积、聚集程度、氧化程度、结合官能团、制造方法、浓度和剂量。目前，对于碳纳米管对人类健康的风险，特别是它们的转化能力，还没有全球共识。可以减轻对碳纳米管的安全担忧。在这种情况下，重要的是要正确看待碳纳米管已知的危害。本文综述了碳纳米管在生物系统中的应用所引起的毒性问题，同时考虑了已经知道的石棉引起的生物损伤机制。
