Satyamurthy N, Bida G T, Phelps M E, Barrio J R
Department of Radiological Sciences, UCLA School of Medicine 90024.
Int J Rad Appl Instrum A. 1990;41(8):733-8. doi: 10.1016/0883-2889(90)90020-h.
N-[18F]fluoro-N-alkylsulfonamides were synthesized by the fluorination of secondary sulfonamides with [18F]F2. Radiochemical yields up to 45% (out of a maximum possible yield of 50%) for these reactions have been realized. The N-[18F]fluorosulfonamides rapidly and regiospecifically fluorinate a variety of Grignard reagents and aryllithium under very mild conditions to give 18F-labeled derivatives in good yields.
N-[¹⁸F]氟代-N-烷基磺酰胺是通过仲磺酰胺与[¹⁸F]F₂的氟化反应合成的。这些反应实现了高达45%的放射化学产率（最高可能产率为50%）。N-[¹⁸F]氟代磺酰胺在非常温和的条件下能快速且区域特异性地使多种格氏试剂和芳基锂氟化，以良好的产率得到¹⁸F标记的衍生物。
