Department of Physiology, School of Medicine, University of Dublin, Trinity College, Dublin 2, Ireland.
Physiol Behav. 2011 Oct 24;104(5):934-41. doi: 10.1016/j.physbeh.2011.06.005. Epub 2011 Jun 23.
Physical activity has been reported to improve cognitive function in humans and rodents, possibly via a brain-derived neurotrophic factor (BDNF)-regulated mechanism. In this study of human subjects, we have assessed the effects of acute and chronic exercise on performance of a face-name matching task, which recruits the hippocampus and associated structures of the medial temporal lobe, and the Stroop word-colour task, which does not, and have assessed circulating concentrations of BDNF and IGF-1 in parallel. The results show that a short period of high-intensity cycling results in enhancements in performance of the face-name matching, but not the Stroop, task. These changes in cognitive function were paralleled by increased concentration of BDNF, but not IGF-1, in the serum of exercising subjects. 3 weeks of cycling training had no effect on cardiovascular fitness, as assessed by VO2 scores, cognitive function, or serum BDNF concentration. Increases in fitness, cognitive function and serum BDNF response to acute exercise were observed following 5 weeks of aerobic training. These data indicate that both acute and chronic exercise improve medial temporal lobe function concomitant with increased concentrations of BDNF in the serum, suggesting a possible functional role for this neurotrophic factor in exercise-induced cognitive enhancement in humans.
身体活动已被报道可改善人类和啮齿动物的认知功能，可能通过脑源性神经营养因子（BDNF）调节机制。在这项人体研究中，我们评估了急性和慢性运动对面孔-名字匹配任务表现的影响，该任务招募海马体和内侧颞叶相关结构，以及不招募海马体和相关结构的斯特鲁普文字-颜色任务，并平行评估了 BDNF 和 IGF-1 的循环浓度。结果表明，短时间的高强度骑行可提高面孔-名字匹配任务的表现，但不能提高斯特鲁普任务的表现。这些认知功能的变化与运动受试者血清中 BDNF 浓度的增加平行，而不是 IGF-1。3 周的骑行训练对心血管健康没有影响，如 VO2 评分、认知功能或血清 BDNF 浓度所示。经过 5 周的有氧运动训练，运动引起的适应性增加、认知功能和血清 BDNF 反应均得到提高。这些数据表明，急性和慢性运动均可改善内侧颞叶功能，同时血清 BDNF 浓度增加，这表明这种神经营养因子在人类运动引起的认知增强中可能具有功能作用。
