Hou Yu-Yi, Ou Hui-Ling, Chu Sau-Tung, Wu Pi-Chuang, Lu Pei-Jung, Chi Chao-Chuan, Leung Kam-Wing, Lee Chien-Yiing, Wu Pi-Hsiung, Hsiao Michael, Ger Luo-Ping
Division of Otology, Department of Otorhinolaryngology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Oct;112(4):484-92. doi: 10.1016/j.tripleo.2011.03.036. Epub 2011 Jul 1.
NAT2, the most important phase II metabolic enzyme for betel quid (BQ), might modify the risk of BQ-related oral and pharyngeal squamous cell carcinoma (OPSCC) in Taiwan.
PCR-RFLP and TaqMan assay were conducted for genotyping of NAT2 in 172 OPSCC cases and 170 healthy controls who habitually chewed BQ.
The genotypic and allelic type of T341C and C481T in NAT2 are associated with the risk of OPSCC. There were linear trends between increased risk of OPSCC and slowness of NAT2 acetylation haplotypes (P = .017), especially for young subjects (P < .001), light BQ chewers (P = .005), light smokers (P = .023), and alcohol drinkers (P = .001). The interactions on risk of OPSCC were found for NAT2 acetylation haplotypes with status of age, BQ chewing, and alcohol drinking.
The NAT2 acetylation haplotypes might be genetic markers for risk of BQ-related OPSCC.
NAT2是槟榔最重要的II期代谢酶，可能会改变台湾地区与槟榔相关的口腔和咽鳞状细胞癌（OPSCC）的风险。
对172例OPSCC病例和170名习惯性咀嚼槟榔的健康对照者进行PCR-RFLP和TaqMan分析，以对NAT2进行基因分型。
NAT2中T341C和C481T的基因型和等位基因类型与OPSCC风险相关。OPSCC风险增加与NAT2乙酰化单倍型的缓慢之间存在线性趋势（P = 0.017），尤其是对于年轻受试者（P < 0.001）、轻度槟榔咀嚼者（P = 0.005）、轻度吸烟者（P = 0.023）和饮酒者（P = 0.001）。发现NAT2乙酰化单倍型与年龄、槟榔咀嚼和饮酒状况之间存在OPSCC风险的相互作用。
NAT2乙酰化单倍型可能是与槟榔相关的OPSCC风险的遗传标记。
