Departments of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan.
Breast. 2011 Dec;20(6):495-500. doi: 10.1016/j.breast.2011.05.003. Epub 2011 Jul 1.
To report our experience with targeted-ultrasound in assessing 142 cases with clustered microcalcifications of intermediate concern detected on digital mammography. All cases had histopathologically-proven microcalcifications within the biopsied or surgical specimens. There were 30%[43/142] breast cancers and 70%[99/142] benign lesions. Only 26%[37/142] of clustered microcalcifications were identified on targeted-ultrasound and other findings including negative study (n = 33), anechoic ducts or cysts (n = 70), dilated ducts with echogenic content (n = 13) and hypoechoic nodules (n = 26). There was no statistical difference of the frequency of negative ultrasound between benign and malignant microcalcifications (P = 0.071). However, only 7.1%[5/70] cases with anechoic ducts or cysts were proven to be breast cancer. The frequencies of depiction of dilated ducts with echogenic foci or hypoechoic nodules were significantly higher for malignant microcalcifications (P < 0.001). Ultrasound was significantly more sensitive for the identification of malignant cases but biopsy of clustered microcalcifications is still warranted when targeted-ultrasound revealed negative findings.
报告我们在数字乳腺摄影检测到的簇状中等大小微钙化灶中应用靶向超声评估 142 例的经验。所有病例均在活检或手术标本中发现有组织病理学证实的微钙化灶。乳腺癌占 30%[43/142]，良性病变占 70%[99/142]。仅在靶向超声上识别出 26%[37/142]的簇状微钙化灶，其他发现包括阴性研究（n = 33）、无回声导管或囊肿（n = 70）、回声增强内容物扩张的导管（n = 13）和低回声结节（n = 26）。良性和恶性微钙化灶的阴性超声频率无统计学差异（P = 0.071）。然而，无回声导管或囊肿中仅 7.1%[5/70]的病例被证实为乳腺癌。恶性微钙化灶显示扩张导管伴回声灶或低回声结节的频率明显更高（P < 0.001）。超声对恶性病例的识别更敏感，但当靶向超声显示阴性结果时，仍需对簇状微钙化灶进行活检。
