Hartmann A, Frenkel J, Hopf R, Baum R P, Hör G, Schneider M, Kaltenbach M
Dept. of Cardiology, Frankfurt University Medical Center, West-Germany.
Int J Card Imaging. 1990;5(4):227-31. doi: 10.1007/BF01797839.
Amyloidosis is a systemic disease frequently involving the myocardium and leading to functional disturbances of the heart. Amyloidosis can mimic other cardiac diseases. A conclusive clinical diagnosis of cardiac involvement can only be made by a combination of different diagnostic methods. In 7 patients with myocardial amyloidosis we used a combined first-pass and static scintigraphy with technetium-99 m-pyrophosphate. There was only insignificant myocardial uptake of the tracer. The first-pass studies however revealed reduced systolic function in 4/7 patients and impaired diastolic function in 6/7 patients. Therefore, although cardiac amyloid could not be demonstrated in the static scintigraphy due to amyloid fibril amount and composition, myocardial functional abnormalities were seen in the first-pass study.
淀粉样变性是一种全身性疾病，常累及心肌并导致心脏功能紊乱。淀粉样变性可模仿其他心脏疾病。心脏受累的确切临床诊断只能通过多种诊断方法的联合使用来做出。在7例心肌淀粉样变性患者中，我们使用了锝-99m焦磷酸盐的首次通过和静态闪烁扫描联合检查。示踪剂在心肌中的摄取量极少。然而，首次通过研究显示，7例患者中有4例收缩功能降低，7例患者中有6例舒张功能受损。因此，尽管由于淀粉样纤维的数量和组成，静态闪烁扫描未能显示心脏淀粉样变性，但首次通过研究中发现了心肌功能异常。
