Faculty of Science and Technology, Free University of Bolzano, 39100, Bolzano, Italy.
Dalton Trans. 2011 Aug 21;40(31):7831-3. doi: 10.1039/c1dt11107h. Epub 2011 Jul 4.
The crystal structure of Helicobacter pylori holo-NikR, a Ni(2+)-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.
幽门螺杆菌全酶 NikR 的晶体结构，一种依赖 Ni(2+)的转录因子，在 pH 7.3 下测定，显示出四个平面正方形的镍结合位点，涉及一个半胱氨酸和三个组氨酸配体。这一观察结果调和了先前在量热数据、非生理 pH 下的结构信息和计算研究之间的不一致。
