Parlani M, Conte B, Majmone S, Maggi C A, Rovero P, Giachetti A
Department of Pharmacology, Menarini Richerche Sud, Rome, Italy.
J Urol. 1990 Dec;144(6):1543-5. doi: 10.1016/s0022-5347(17)39795-1.
The contractile response to natural tachykinins [substance P (SP), neurokinin A (NKA), arginin-neurokinin B (ArgNKB)] and to synthetic peptide [Pro9]SP sulfone, [beta Ala8]NKA(4-10) and [MePhe7]NKB, were investigated in the isolated smooth muscle from the human prostatic urethra. Natural tachykinins evoked concentration-related responses with the following order of potency: NKA----NKB--------SP. Among selective agonists [beta Ala8]NKA(4-10) produced concentration-related contractions, while [Pro9]SP sulfone and [MePhe7]NKB were inactive. These data indicate the presence of NK-2 receptors in the smooth muscle of the human prostatic urethra.
在人前列腺尿道的离体平滑肌中，研究了对天然速激肽（P物质（SP）、神经激肽A（NKA）、精氨酸神经激肽B（ArgNKB））以及合成肽[Pro9]SP砜、[β丙氨酸8]NKA(4 - 10)和[甲基苯丙氨酸7]NKB的收缩反应。天然速激肽引起浓度相关反应，其效力顺序如下：NKA----NKB--------SP。在选择性激动剂中，[β丙氨酸8]NKA(4 - 10)产生浓度相关的收缩，而[Pro9]SP砜和[甲基苯丙氨酸7]NKB无活性。这些数据表明人前列腺尿道平滑肌中存在NK - 2受体。
