Keep Richard F, Xi G, Hua Y, Xiang J
Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109-2200, USA.
Acta Neurochir Suppl. 2011;111:71-5. doi: 10.1007/978-3-7091-0693-8_12.
Following intracerebral hemorrhage (ICH) there is a sequential response involving activation of the coagulation cascade/platelet plug formation, vascular repair, upregulation of endogenous defense mechanisms and clot resolution. How these responses are coordinated and modified by different hematoma sizes has received little attention. This paper reviews evidence that thrombin can modulate and may coordinate the components of the endogenous response. This has potential consequences for treatment of ICH with a number of modalities.
脑出血（ICH）后会出现一系列反应，包括凝血级联反应的激活/血小板栓子形成、血管修复、内源性防御机制上调以及血凝块溶解。不同血肿大小如何协调和改变这些反应鲜受关注。本文综述了凝血酶可调节并可能协调内源性反应各成分的证据。这对多种治疗方式治疗脑出血具有潜在影响。
